| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0220 | CD253/ TNFSF10/ TRAIL, Human, Recombinant | 10ug |
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| 分子量 | 19.5 kDa |
|---|---|
| 表观分子量 | 16 kDa |
| 片段与标签 | Arg115-Gly281 |
| 生物活性 | Testing in progress |
| 物种 | Human |
| 表达宿主 | E.coli |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20℃, though stable at room temperature for 3 weeks.＜br/ >Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.＜br/ >Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months |
产品介绍
Human TNFSF10 is a type II transmembrane Protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct Receptors. Two of these Receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/ TRICK2), are plasma membrane Proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
