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IL-36γ/ IL-1F9, Human, Recombinant

  • 货号:KR0196
货号 产品名称 规格 库存 价格 数量 购买
KR0196 IL-36γ/ IL-1F9, Human, Recombinant 10ug

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分子量 17.0 kDa
表观分子量 14-16 kDa
片段与标签 Ser18-Asp169
生物活性 Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is less than 20 ng/ ml.
物种 Human
表达宿主 E.coli

 

产品特性

 

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 <1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months

 

产品介绍

Interleukin-36 gamma (IL-36γ) is a member of the Interleukin 1 Cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in both neuronal and synovial tissue, whereas IL-36β and IL-36γ are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36β and IL-36γ stimulate proliferation, maturation and/ or Cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36α is mediated by Interleukin 1 Receptor-like 2 (IL1RL2/ IL1R-rp2), and is specifically inhibited by Interleukin 1 family, member 5 (IL1F5/ IL-1 delta). IL-36γ plays an important role in communicating the cell death to surrounding cells.

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