| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0156 | IL-36RN/ IL-1F5, Human, Recombinant | 10ug |
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| 分子量 | 16.9 kDa |
|---|---|
| 表观分子量 | 16 kDa |
| 片段与标签 | Met1-Asp155 |
| 生物活性 | Measured by its ability to inhibit IL-36 alpha, IL-36 beta or IL-36 gamma -induced IL-8 secretion in A431 human epithelial carcinoma cellsThe ED50 for this effect is less than 500 ng/ ml in the presence of 10 ng/ mL of recombinant human IL-36 beta. |
| 物种 | Human |
| 表达宿主 | E.coli |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20°C, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at ＜ -20°C for 3 months. |
产品介绍
Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted Protein which belongs to the Interleukin 1 Cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 Receptor-related Protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member Ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence i
