| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0126 | GRO-β/ CINC-3/ CXCL2, Human, Recombinant | 10ug |
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| 分子量 | 7.67 kDa |
|---|---|
| 表观分子量 | 10 kDa |
| 片段与标签 | Thr39-Asn107 |
| 生物活性 | Measured by its ability to activate chimeric Receptor and induce reporter gene expression in HEK293 cell line used Splite TEV activity detection platform.The ED50 for this effect is less than 10 ng/ mL. |
| 物种 | Human |
| 表达宿主 | E.coli |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20°C, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at ＜ -20°C for 3 months. |
产品介绍
Chemokine Ligand 2 (CXCL2) is a small secreted Cytokine which belongs to the CXC Chemokine family. It is secreted by monocytes and macrophages and chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. CXCL2 mobilizes cells by interacting with a cell surface Chemokine Receptor called CXCR2. It has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. It is a hematoregulatory Chemokine, which suppresses hematopoietic progenitor cell proliferation. It can be induced by Receptor activator of NF-kappaB Ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-Derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
